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Endoret inhibits apoptotic signaling pathway in Ab-stimulated neuronal cultures.

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posted on 2013-09-19, 03:05 authored by Eduardo Anitua, Consuelo Pascual, Rocio Pérez-Gonzalez, Desiree Antequera, Sabino Padilla, Gorka Orive, Eva Carro

A. 7.5 and 10% Endoret treatment protects against Ab1-42 (10 µM)-induced cell death in neuronal cell culture assayed with a cell death ELISA. B. Fluorescent images of living cells (green) and dead cells (red) in neuronal cultures in control condition (B27), and after addition of Ab1-42 (10 µM), and 7.5 and 10% Endoret. C. Quantification of Ab1-42-induced cell death after 48 h in vitro. Representative blots and quantitative analysis of (D) caspase-3, and (E) HSP-70 expression in neuronal cultures treated with Aβ42 (10 µM) and 7.5 and 10% Endoret. One representative experiment is shown (n = 3 experiments). Data show mean ± SEM; *p<0.05 and **p<0.01 vs control culture. #p<0.05 and # #p<0.01 vs Aβ42 -treated culture.

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