Endocrine cell mass and characteristics of islet architecture.
A: Inter-subject comparison. Total islet cell composition (beta-cells in green, alpha-cells in red, and delta-cells in blue) in individual non-diabetic subjects (a) and T2D patients (b). B: Morphological changes observed in large islets. Representative islets are pseudo-colored models of actual islets based on immunohistochemical images composed of beta-cells (green), alpha-cells (red), and delta-cells (white). From left to right: compacted endocrine cell arrangement, relatively sparse architecture, the presence of a population of cells lacking cytosolic hormones (blue), and cyst formation containing necrotic materials (purple). Corresponding small islets from the same sections in a to d are shown in e to h.