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Effects of high doses of MNK inhibitor and rapamycin on VSV replication.

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posted on 21.02.2013, 01:09 by Sabrina Marozin, Enrico N. De Toni, Antonia Rizzani, Jennifer Altomonte, Alexandra Junger, Günter Schneider, Wolfgang E. Thasler, Nobuyuki Kato, Roland M. Schmid, Oliver Ebert

HCC cells (HepG2 and Huh-7) and immortalized human hepatocytes (PH5CH8) were mock-treated (DMSO) or treated with increasing concentrations of MNK inhibitor and rapamycin until the appearance of cytotoxicity. Cultures were infected with VSV-wt at an MOI of 0.1 and viral titers were determined 24 hr post-infection by TCID 50. Data represent the average of three independent experiments.