Effects of L-NAC on the death of glutathione S transferase (GST)-knockdown C6/36 cells with dengue 2 virus (DENV-2) infection.

(A) When GST-knockdown C6/36 cells were treated with L-NAC, the apoptosis rate was no higher than 5.69% (at 48 h post-infection; hpi) in infected cells. (B) In contrast, DENV-2 infection without treatment resulted in 10.45% and 11.08% apoptosis rates at 36 and 48 hpi, respectively. (C) Apoptotic effect of L-NAC was not evident on uninfected cells.