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Effects of Boc5 on insulin secretion and insulin sensitivity.

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posted on 2008-08-06, 01:25 authored by Haoran Su, Min He, Hongmei Li, Qing Liu, Jia Wang, Yiqian Wang, Weiwei Gao, Ling Zhou, Jiayu Liao, Andrew A. Young, Ming-Wei Wang

(A) Effect of prior administration of Boc5 on insulinogenic index, the slope of the relationship between plasma insulin and blood glucose concentrations in quasi-steady-state, during the decay phase of an intraperitoneal (i.p.) glucose challenge in fasted C57BL/6J (C57) mice. (B) Dose response for effects of Boc5 and exendin-4 on insulinogenic index in C57 mice during an i.p. glucose challenge. (C) Effect of prior administration of exendin-4 and Boc5 on insulinogenic index in fasted db/db mice. Gray band depicts the slope range of different Boc5 doses (0.3, 1, 3 and 6 mg). (D) Dose response for effects of Boc5 and exendin-4 on insulinogenic index in db/db mice during an i.p. glucose challenge. (E) Dose response for effect of 4-week prior administration of Boc5 on fasting insulin concentrations in db/db (open circles) and non-diabetic C57 mice (closed circles). (F) Dose response for effect of Boc5 on HOMAir, an index of insulin resistance derived from fasting insulin and glucose concentrations. (G) Dose response for effect of 4-week prior Boc5 administration on QUICKI, an alternate index of insulin sensitivity derived from fasting insulin and glucose concentrations. (H) Effect of 4-week administration of Boc5 (3 mg/day) on Kitt, a measure of insulin-mediated glucose clearance, in C57 and db/db mice.

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