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Effects of Beclin-1 haploinsufficiency on AR113Q muscle.

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posted on 2011-10-13, 01:28 authored by Zhigang Yu, Adrienne M. Wang, Hiroaki Adachi, Masahisa Katsuno, Gen Sobue, Zhenyu Yue, Diane M. Robins, Andrew P. Lieberman

A. Muscle fiber size (100 fibers/mouse) was quantified from proximal hind limb muscle of AR113Q (red, n = 6) or AR113Q, Beclin-1 +/− (blue, n = 6) mice at 16 wks. Left panel shows fiber size distribution, and right panel shows relative fiber cross sectional area (mean +/− SEM). Left panel, p<0.0001 by Mann-Whitney test. Right panel, p<0.0001 by Student's t test. B. AR expression in skeletal muscle of 16 wk mice was assessed by western blot. GAPDH controls for loading. Right panel shows quantification of signal relative to GAPDH (mean +/− SEM). Differences not significant (n. s.).

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