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Effects of 1-methoxyoctadecan-1-ol on calpain activation, STEP cleavage and p38 MAPK phosphorylation.

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posted on 2014-01-08, 03:56 authored by Ji Yeon Jang, Young Whan Choi, Ha Neui Kim, Yu Ri Kim, Jin Woo Hong, Dong Won Bae, Se Jin Park, Hwa Kyoung Shin, Byung Tae Choi

The significant calpain1 activation (A), STEP cleavage (B) and p38 MAPK phosphorylation (C) were shown in the ipsilateral (Ipsil) cerebral hemisphere of photothrombotic ischemic mice compared with the contralateral (Con). **P<0.01, ***P<0.001, vs. vehicle group, Data are expressed as mean±SEM of three separate experiments.

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Neuroprotective Effects of a Novel Single Compound 1-Methoxyoctadecan-1-ol Isolated from Uncaria sinensis in Primary Cortical Neurons and a Photothrombotic Ischemia Model
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Molecular cell biologySignal transductionSignaling cascadesMAPK signaling cascadesphytochemistryPhytopharmacologyDrugs and devicesDrug research and developmentNeuropharmacologyPharmacodynamicsneurologyCerebrovascular diseases1-methoxyoctadecan-1-olcalpaincleavagep38mapk

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