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Effect of silenced p65 on IGF-1-induced expression of downstream NF-κB targets in Panc02 cells.

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posted on 07.05.2014, 03:38 by Alison E. Harvey, Laura M. Lashinger, Drew Hays, Lauren M. Harrison, Kimberly Lewis, Susan M. Fischer, Stephen D. Hursting

A, Expression of p65 mRNA in Panc02 cells after exposure to either scrambled or p65-specific small interfering RNA. B, Ccdn1; Vegfa; Birc5; and COX-2 mRNA expression after 18-hour IGF-1 treatment (400 ng/mL). Bar graphs represent mean ± SEM (n = 3 separate experiments performed in triplicate for each gene). Different letters or asterisk denotes significance between groups. IGF-1, Insulin-like growth factor-1.