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Effect of retinal detachment on electrophysiological properties of Müller cells.

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posted on 07.10.2009, 00:20 by Abdoulaye Sene, Ramin Tadayoni, Thomas Pannicke, Antje Wurm, Brahim El Mathari, Romain Benard, Michel Joseph Roux, David Yaffe, Dominique Mornet, Andreas Reichenbach, Jose-Alain Sahel, Alvaro Rendon

The cells were isolated from control and detached retina of wt and Dp71-null mice and were investigated 7 days after surgery. A: Examples of membrane currents evoked by depolarizing and hyperpolarizing voltage steps from a holding potential of −80 mV to potentials between −180 and +20 mV. No strong alterations of current kinetics were observed. B: Inward current amplitudes recorded at a −60 mV hyperpolarizing step. A weakly significant decrease was observed in cells from wt mice. C: Membrane capacitances were increased after retinal detachment in Müller cells from wt and Dp71-null mice. D: Resulting from decreased currents and increased capacitances, inward current densities were significantly reduced. Current densities were calculated from the data shown in B and C. Each bar represents mean values with standard deviations of 12 cells from 3 mice. Significant differences after retinal detachment versus the respective untreated control: * p<0.05, ** p<0.01, *** p<0.001.

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