Effect of proteasome inhibitors on CFTR immunostaining.

Histochemical staining of CFTR in ileum from FVB wild type mice (A); ileum from untreated homozygous Cftr^tm1Eur F508del mice (B); ileum from homozygous Cftr^tm1Cam knockout mice (C); PI-treated ileum from homozygous Cftr^tm1Eur F508del mice (D–G); ileum was treated for 4 h at 37°C with 1 µM epoxomicin (D), 10 µM MG-132 (E), 20 µM ALLN (F), or 30 nM PS341 (G). Panel H: Vehicle-treated (0.1% DMSO) ileum from homozygous Cftr^tm1Eur (FVB) F508del mice. Magnifications: 200×.