Effect of olanzapine on plasma leptin.

Baseline fasting blood samples were drawn approximately 10–12 h following the final dose of olanzapine or placebo tablets. Plasma leptin was measured at the conclusion of the study for each subject under placebo- and olanzapine-treated conditions. Data are expressed as a box plot for placebo and olanzapine-treated subjects. An asterisk indicates (P = 0.02) a significant difference between the medians of the placebo and olanzapine groups using a Wilcoxon matched-pairs signed rank test (n = 15).