Figure_5.tif (293.82 kB)
Download file

Effect of inhibition of JNK pathway on IL-6 induced increase in Caco-2 TJ permeability.

Download (0 kB)
figure
posted on 2014-03-24, 02:54 authored by Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma

(A) Pre-treatment with JNK inhibitor SP-600125 (25 µM) prevented the IL-6 induced increase in claudin-2 protein expression. (B) SP-600125 pre-treatment prevented the IL-6 induced drop in Caco-2 TER (n = 6). *, p<0.001 vs. control; **, p<001 vs. IL-6 treatment. (C) SP-600125 pre-treatment prevented the IL-6 induced increase in urea flux in filter-grown Caco-2 monolayers. (n = 6). *, p<0.001 vs. control; **, p<001 vs. IL-6 treatment.

History