Effect of antibody mediated neutralization of IFN-γ on SEB-induced cytokine and chemokine responses in vivo.

Age-matched HLA-DR3 transgenic mice were challenged with SEB (5 µg) immediately followed by 100 µg of goat anti-mouse IFN-γ or control goat antibodies. Mice were bled 3 hrs later and serum cytokine levels were determined using a multiplex suspension array system (Bio-Plex, Bio-Rad). Each bar represents the mean±SE of 4–6 mice.