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Effect of OSM or CNTF treatment on PERG after ON-crush.

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posted on 22.09.2014 by Xin Xia, Rong Wen, Tsung-Han Chou, Yiwen Li, Zhengying Wang, Vittorio Porciatti

OSM (3 µg in 2 µl) or CNTF (3 µg in 2 µl) was delivered intravitreally immediately after 1-s ON-crush. Eyes of control animals received PBS (2 µl). PERG was recorded before ON-crush as baseline and at 8, 15, 22 days after ON-crush. A: grand-average PERG waveforms recorded in PBS-, OSM-, and CNTF-treated eyes before and at different times after ON-crush. B: mean PERG amplitude as a function of time in PBS-, OSM-, and CNTF-treated groups. Eight days after ON-crush, the PERG amplitude was in the noise range (hatched area) in the PBS-treated group. However, in both OSM- and CNTF-treated groups, the PERG amplitudes were significantly higher (P = 0.003) than that of the PBS-treated group. By day 15 and 22, the PERG amplitudes were at or close to the noise range in all groups. Error bars represent the SEM (n = 6).