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Effect of EE housing on retinal dysfunction induced by experimental diabetes.

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posted on 2014-07-08, 03:12 authored by Damián Dorfman, Marcos L. Aranda, María Florencia González Fleitas, Mónica S. Chianelli, Diego C. Fernandez, Pablo H. Sande, Ruth E. Rosenstein

ERGs (A) and OPs (C) were weekly registered after the induction of diabetes. Experimental diabetes induced a significant decrease in ERG a- and b-wave amplitude in eyes from animals housed in SE (black circles), as compared with age-matched control animals (grey bar), after 5 weeks of STZ injection. In diabetic eyes from animals housed in EE (white circles), a significant prevention of these alterations was observed. Panel B shows representative scotopic ERG traces from control and diabetic animals housed in SE (DBT+SE) or EE (DBT+EE) assessed at 6 and 10 weeks after diabetes induction. A significant decrease in the sum of OP amplitude (C) was observed after 5 weeks of diabetes onset in eyes from animals housed in SE, while EE housing prevented the effect of diabetes on this parameter. Panel D shows representative OP traces from control and diabetic animals housed in SE or EE and assessed at 6 and 10 weeks after induction of diabetes. Data are the mean ± SEM (n = 10–12 animals per group); *p<0.05, **p<0.01 versus age-matched control; a: p<0.01 versus diabetic animals in SE, by Tukey's test.

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