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Effect of C3-pretreatment on the thrombin-induced inhibition of mechanical stimulation-induced -wave propagation in BCEC.

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posted on 20.02.2013, 01:39 by Raf Ponsaerts, Catheleyne D’hondt, Fréderic Hertens, Jan B. Parys, Luc Leybaert, Johan Vereecke, Bernard Himpens, Geert Bultynck

Quantitative analysis of the total spreading of the mechanical stimulation-triggered wave, presented as active area (AA) normalized to the control condition (100%) in untreated (white bars) and thrombin-treated (black bars) BCEC, either in control conditions or in C3-pretreated conditions. indicates that thrombin significantly (P 0.001) inhibits -wave propagation. indicates that C3 significantly (p 0.001) alleviates the thrombin-induced inhibition of -wave propagation.