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Effect of BV administration after hemorrhagic shock and resuscitation (HSR) in the lungs.

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posted on 07.05.2013, 02:25 by Junko Kosaka, Hiroshi Morimatsu, Toru Takahashi, Hiroko Shimizu, Susumu Kawanishi, Emiko Omori, Yasumasa Endo, Naofumi Tamaki, Manabu Morita, Kiyoshi Morita

The rats were randomly divided into two groups: a HSR/Vehicle group, which was administered vehicle after HSR, and a HSR/BV group, which was administered BV after HSR. BV (35 mg/kg) or vehicle was injected via the femoral vein after resuscitation. (A) Representative images from five independent experiments (hematoxylin–eosin staining, original magnification ×200, scale bar  = 100 µm). (B) lung histopathological score 12 h after HSR. (C) Mitochondrial 8-OHdG levels in the lungs 3 h after HSR. Data are presented as means ± standard deviation (n = 5 per group). Statistical analysis was performed using Student’s t-test. *p<0.05 vs. HSR/Vehicle.