Effect of BV administration after hemorrhagic shock and resuscitation (HSR) in the lungs.
The rats were randomly divided into two groups: a HSR/Vehicle group, which was administered vehicle after HSR, and a HSR/BV group, which was administered BV after HSR. BV (35 mg/kg) or vehicle was injected via the femoral vein after resuscitation. (A) Representative images from five independent experiments (hematoxylin–eosin staining, original magnification ×200, scale bar = 100 µm). (B) lung histopathological score 12 h after HSR. (C) Mitochondrial 8-OHdG levels in the lungs 3 h after HSR. Data are presented as means ± standard deviation (n = 5 per group). Statistical analysis was performed using Student’s t-test. *p<0.05 vs. HSR/Vehicle.