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Dynamics of HIV-1 RNA levels in subjects with high early viral set point, n = 14.

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posted on 12.04.2010 by Vladimir Novitsky, Rui Wang, Hermann Bussmann, Shahin Lockman, Marianna Baum, Roger Shapiro, Ibou Thior, Carolyn Wester, C. William Wester, Anthony Ogwu, Aida Asmelash, Rosemary Musonda, Adriana Campa, Sikhulile Moyo, Erik van Widenfelt, Madisa Mine, Claire Moffat, Mompati Mmalane, Joseph Makhema, Richard Marlink, Peter Gilbert, George R. Seage III, Victor DeGruttola, M. Essex

High HIV RNA level was considered at ≥50,000 (4.7 log10) copies/ml. Early viral set point was determined as a mean value from 50 to 200 days p/s. Data for each subject is presented in a separate graph. Patient code is shown at the top left of each graph. Y-axis shows HIV-1 RNA levels, log10 copies/ml; scale is uniform for all subjects; the 50,000 (4.7 log10) copy threshold is shown as a dashed line. X-axis denotes days from estimated seroconversion; scale differs between subjects due to differences in the follow-up period. Filled circles delineate pre-cART HIV-1 RNA values, and open circles show post-cART HIV-1 RNA values. Time of cART is highlighted by gray zone, if applicable. For calculation of slopes and prediction of time of decline to the threshold of 50,000 (4.7 log10) copies, only pre-cART data were used. The conservative estimate of individual time to decline below 50,000 (4.7 log10) copies is shown under the patient code with the less conservative Kaplan-Meier estimate in brackets (if it differs from the conservative estimate).