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Downregulation of GSK3 is associated with MAFA upregulation.

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posted on 13.04.2015, 06:11 by Gili Nathan, Sharon Kredo-Russo, Tamar Geiger, Ayelet Lenz, Haggai Kaspi, Eran Hornstein, Shimon Efrat

A,B. Immunoblotting of MAFA in expanded islet cells infected at passages 4–6 with miR-375 or empty viral vectors. Values are mean±SE (n = 3 donors). C,D. Immunoblotting of MAFA in expanded islet cells treated at passages 3–7 for 48h with the GSK-3 inhibitor SB-216763 at the indicated concentrations. Values are mean±SE (n = 3 donors). E. Suggested model for activation of insulin expression by miR-375-mediated inhibition of GSK3.

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