Dose response testing of selected compounds.
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posted on 2015-04-30, 03:12 authored by Kyle C. Wilcox, Matthew R. Marunde, Aditi Das, Pauline T. Velasco, Benjamin D. Kuhns, Michael T. Marty, Haoming Jiang, Chi-Hao Luan, Stephen G. Sligar, William L. KleinOf fifteen compounds surviving dose-response potency testing, five commercially-available molecules were repurchased for further analysis. (a) The names and EC50 values of each are listed with the corresponding panel identifier. (b-f) Individual dose response curves and chemical structures corresponding to compounds listed in panel a. Vertical lines mark the EC50 values in each plot.
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synaptic membrane proteinsnanoscale lipid bilayersantagonistsolubilized synaptic membrane proteomealzheimerSMPL Nanodisc systemmembrane protein libraryNanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screenhtsmembrane protein targetsligand binding activitynerve cell culturesSMPL Nanodiscsbind SMPL Nanodiscs
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