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Dopamine and a D1-agonist induce similar changes in lens refractive power.

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posted on 21.02.2013 by J. Marcus Schartau, Ronald H. H. Kröger, Bodil Sjögreen

(A) Mean ΔBCD curves from 31 lens pairs where one lens was treated with dopamine, D1-agonist, or D2-agonist, as well as pairs where both lenses were untreated (control). Treatment with the D1-agonist SKF-38393 induced an effect similar to that of dopamine in that BCD values increased in the lens cortex, BEP 0.60–0.95. Both treatments thus reduced the refractive power in the cortex compared to untreated lenses. The D2-agonist quinpirole had no effect. The curves represent the mean ΔBCDs from 31 animals (Control: n = 8, D1: n = 7, D2: n = 7, D: n = 9). (B) Max-ΔBCD values and standard deviation in the control and treatment groups. There was no significant (n.s) difference between max-BCD values from dopamine and D1-agonist treatments or between the control and D2-agonist. ** = Significance level 0.01%, *** = significance level 0.001% (n = 31).

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