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Dopamine D1 receptors mediate the light-sensitive response gain of outer retina.

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posted on 19.11.2013, 03:21 by Quanhua He, Hong-ping Xu, Ping Wang, Ning Tian

The b-wave/a-wave ratios and OPs/b-waves ratios of WT and D1−/− mice raised under cyclic light/dark conditions and constant darkness were used to assess the effects of light deprivation on the response gains of ERG. A: The b-wave/a-wave ratios of WT mice raised under cyclic light/dark conditions and constant darkness were plotted as a function of the light intensity showing a significant increase of the outer retina response gain at the light intensities of 0.008–0.08 cd*s/m2. B: The OPs/b-wave ratios of WT mice raised under cyclic light/dark conditions and constant darkness. C: The b-wave/a-wave ratios of D1−/− mice raised under cyclic light/dark conditions and constant darkness showing a significant decrease of the outer retina response gain at the light intensities of 0.08–0.25 cd*s/m2. D: The OPs/b-wave ratios of D1−/− mice raised under cyclic light/dark conditions and constant darkness. E: The b-wave/a-wave ratios of D1−/− mice raised in constant dark were normalized to D1−/− mice raised in cyclic light/dark conditions while the b-wave/a-wave ratios of WT mice raised in constant dark were normalized to WT mice raised in cyclic light/dark conditions. The two normalized b-wave/a-wave curves were plotted as functions of light intensities and showed that light deprivation significantly increased the b-wave/a-wave ratios of light responses evoked by low light intensities in WT but not D1−/− mice. F: The OPs/b-wave ratios of D1−/− and WT mice raised in constant dark were normalized to control mice raised in cyclic light/dark conditions, respectively, and plotted as functions of light intensities.

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