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Differential effect of CDK inhibitors on VRK1 and VRK2 and discrimination between VRK1 and VRK2 by staurosporine.

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posted on 2011-08-04, 02:40 authored by Marta Vázquez-Cedeira, Iria Barcia-Sanjurjo, Marta Sanz-García, Ramiro Barcia, Pedro A. Lazo

A. Inhibition of VRK2 by Cdk1 inhibitor. Quantification of the inhibition achieved on autophosphorylation and histone H3 phosphorylation is shown in the graph below. Quantification was performed in the linear response range. B. Inhibition of VRK2A by roscovitine, an inhibitor in phase II clinical trials. Quantification of the inhibition achieved on autophosphorylation and histone H3 phosphorylation is shown in the graph below. C. Inhibition of VRK1 activity by staurosporine. At the bottom the quantification in the linear response range is shown. D. Lack of effect of staurosporine on VRK2A activity. At the bottom the quantification in the linear response range is shown.

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