Diagram of the proposed model.
Schematic diagram of the proposed model (M0). The rounded edge rectangles represent the different compartments in the model connected with arrows showing the direction of the CA fluxes, with the associated rate parameters. The Hepatocyte compartment represents all intracellular water within the liver, and the Splenic IS represents the structures within the spleen that are inaccessible to EOB. The white pointed rectangle (CA Injection) represents the administration of EOB to the system. The white circles are the sinks of the system, meaning that once the CA has reached the ‘Urine’ and ‘Bile’ compartments it cannot be transferred back into the system. The signal model is represented by the dashed grey boxes (liver, vein and spleen respectively), showing the congregation of compartments for the conversion from CA concentration to relative change in relaxivity that is comparable to the data from the ROIs. The fractions of the compartments used in each MRI signal simulation can be found in Table 2. Both the plasma and EES compartments are shared between the liver and spleen MRI signals.