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Diagram of p38 MAPK regulation of wound healing on native collagen and 3DG-collagen.

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posted on 20.02.2013, 18:34 by Danielle T. Loughlin, Carol M. Artlett

Under normal wound healing phosphorylation of p38 MAPK activates AKT and ERK1/2 to promote migration, proliferation, and collagen production. During diabetic wound healing, 3DG-collagen negatively impacts the dermal fibroblast by phosphorylating p38 MAPK to downregulate the expression of ERK1/2 and AKT and promote reduced cell proliferation and migration.

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