Detection of persistent infection of MusPV1 despite absence of papilloma.
Schedules of T cell depletion using anti-CD4/CD8/CD3 monoclonal antibody and the timing of MusPV1 challenge and virus measurements in BALB/c mice. Challenge of nude mice was used as a positive control (A). MusPV1 E6/E7 transcripts were detected in wart bearing nude mice (B) but not wildtype infected mice (no depletion) (C). Low levels of MusPV1 E6/E7 transcripts were present in CD4+ T cell-depleted mice (D), but not those depleted of CD8+ T cells (E).