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Decreased memory capability in mice over expressing miR132.

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posted on 20.02.2013, 22:11 by Katelin F. Hansen, Kensuke Sakamoto, Gary A. Wayman, Soren Impey, Karl Obrietan

Memory in tTA::miR132 bitransgenic mice was measured by novel object recognition. In contrast to monotransgenic littermates (tTA and miR132), which spent more time exploring novel objects than familiar ones, tTA::miR132 mice showed no significant capacity for object discrimination. Data are presented as mean discrimination ratio ±SEM, ANOVA F(2,15)  = 7.351, *p<.006, n = 6 for each group.