Decreased memory capability in mice over expressing miR132.
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posted on 2013-02-20, 22:11 authored by Katelin F. Hansen, Kensuke Sakamoto, Gary A. Wayman, Soren Impey, Karl ObrietanMemory in tTA::miR132 bitransgenic mice was measured by novel object recognition. In contrast to monotransgenic littermates (tTA and miR132), which spent more time exploring novel objects than familiar ones, tTA::miR132 mice showed no significant capacity for object discrimination. Data are presented as mean discrimination ratio ±SEM, ANOVA F(2,15) = 7.351, *p<.006, n = 6 for each group.
