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Decreased dendritic spine density in the mature cortex of Cln6nclf mice.

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posted on 01.11.2013, 03:14 by Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer

Golgi impregnation was used to label dendritic spines on the primary dendrite of excitatory cortical projection neurons in age-matched 2 month controls (A) and Cln6nclf (B) mice. (C) The Cln6nclf mutant mouse excitatory pyramidal neurons have reduced spine density. [Mean spine density +/− SEM, n = 40 neurons counted per genotype (***p≤0.0001)].