Decreased dendritic spine density in the mature cortex of <i>Cln6<sup>nclf</sup></i> mice.
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posted on 2013-11-01, 03:14 authored by Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer<p>Golgi impregnation was used to label dendritic spines on the primary dendrite of excitatory cortical projection neurons in age-matched 2 month controls (<b>A</b>) and <i>Cln6<sup>nclf</sup></i> (<b>B</b>) mice. <b>(C)</b> The <i>Cln6<sup>nclf</sup></i> mutant mouse excitatory pyramidal neurons have reduced spine density. [Mean spine density +/− SEM, <i>n</i> = 40 neurons counted per genotype (***<i>p</i>≤0.0001)].</p>
