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Deactivation of NvShak currents.

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posted on 2012-12-10, 14:48 authored by Timothy Jegla, Heather Q. Marlow, Bihan Chen, David K. Simmons, Sarah M. Jacobo, Mark Q. Martindale

(a–g) Tail currents recorded from excised inside-out patches at −160, −140, −120, −100 and −80 mV are shown for NvShak1-6 and mouse Kv1.2. Channels were activated with a test pulse to +50 mV and recordings were made in symmetrical 140 mM K+. Scale bars indicate current amplitude and time. (h) Time constants from single exponential fits of tail current decay are plotted vs. voltage. The slope of the relationship in the semi-logarithmic plot is proportional to voltage-dependence of the closing transition and is qualitatively similar for all channels. Values show mean ± S.E.M. (n = 5−7). NvShak channels displayed ∼10-fold variation in deactivation rate from NvShak6 (fastest) to NvShak1 (Slowest).

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