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De novo UMP synthesis in S. pombe involves six steps and five enzymes.

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posted on 22.03.2013, 03:45 authored by Yuzy Matsuo, Kouhei Nishino, Kouhei Mizuno, Takashi Akihiro, Takashi Toda, Yasuhiro Matsuo, Tomohiro Kaino, Makoto Kawamukai

The de novo synthesis of UMP in S. pombe is outlined. Ura1 is a bi-functional enzyme consisting of carbamoyl phosphate synthetase I and aspartate transcarbamoylase, Ura2 is dihydroorotase, Ura3 is dihydroorotate dehydrogenase that requires quinone as a cofactor and localizes in mitochondria, Ura5 is orotate phosphoribosyltransferase, and Ura4 is OMP decarboxylase.

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