DNase landscape of OTX2-expressing and -nonexpressing cell lines.
DNase hypersensitivity map of (A) the OTX2 locus and (B) a region of chromosome 14 exhibiting DHS sites that are shared among the three cell lines shown. From top to bottom, tracks are as follows: Refseq genes, D341 medulloblastoma (Medullo) cells, D721 medulloblastoma cells, H54 glioblastoma (GBM) cells, MultiZ vertebrate alignments, PhyloP vertebrate conservation, CpG islands. Orange bars indicate regions of consistent and robust DNase hypersensitivity in the two medulloblastoma cell lines. Grey bar indicates DHS “R”, also found in retinoblastoma (Fig. S1A). Genomic coordinates are indicated below tracks. Carat indicates CpG island subjected to methylation analysis (Fig. 5 and Table S2). See Fig. S1A for extended viewing range.