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DNA-methylation results in the short-term rhGH treatment study cohort using an individualised evaluation approach.

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posted on 18.03.2015, 02:55 by Julia Kolarova, Ole Ammerpohl, Jana Gutwein, Maik Welzel, Inka Baus, Felix G. Riepe, Thomas Eggermann, Almuth Caliebe, Paul-Martin Holterhus, Reiner Siebert, Susanne Bens

Differences of avg.beta values between stimulated and baseline samples (delta beta) of each pair were calculated. Depicted are those loci, in which at least 3/24 analysed sample pairs showed absolute delta beta values below -0.1 or above 0.1 (roughly corresponding to a difference of DNA-methylation of +/- 10% between each analysed sample pair) and in which at least 3 CpGs were affected per gene (n = 259). Red: delta beta values above 0.2, pale red: delta beta values between 0.1 and 0.2. Blue: delta beta values below -0.2, pale blue: delta beta values between -0.1 and -0.2. Samples are sorted according to Table 1 with P1 at the left margin and P26 at the right margin. Those loci used for bisulfite pyrosequencing validation are zoomed out and shown at the right side of the figure.