DBL homology block alignment.

HBs in 1043 DBL sequences aligned, and sorted by NJ-clustering based on differences in HB composition. Tree distances show the number of different HBs in the DBL domains. The sequences are divided into 6 segments by the conserved core HB1–5 (Figure 5), and the corresponding subdomain parts are noted below the alignment. Only the 80 most frequent of 378 HBs are colored. Sequence conservation logos as described in Figure 5 are shown for selected HBs, where number tabs indicate the HB number. Logos are when possible placed in order of appearance in the alignment. Letters next to the tree identifies groups marked by dots in the tree, matching domain subclassification based on amino acid alignments: (a) ζ3, (b) ζ5, (c) ζ6, (d) ζ4, (e) ζ1, (f) ζ2, (g) δ5, (h) δ4/8/9, (i) γ7, (j) γ11/15, (k) γ1, (l) γ2/9, (m) γ8, (n) γ5/6/12/16/17, (o) ε2, (p) ε7, (q) ε4, (r) pam6/ε3, (s) pam5/ε5/ε12, (t) ε6/9, (u) ε1/11/13. The green pointers mark products of recombination between DBLγ and DBLβ domains, with break point around HB2. Additional information for all HBs can be found by querying the VarDom server with the HB numbers, as given in the legend or on the logos. Labeled homology block alignments can be found in Figure S7.