Cyclin D1 and cyclin E expression were significantly decreased in A549 cells with knocked down p120ctn.

(A) The results of western blot analysis showed that proteins cyclin D1 (*, p = 0.001) and cyclin E (*, p = 0.004) were significantly decreased after p120ctn was knocked down in A549 cells. (B and C) The results of MTT and flow cytometry showed suppressed cell proliferative ability, increased G₁ phase cells (*, p = 0.001) and reduced S phase cells (*, p = 0.001) were detected in A549 cells with knocked down p120ctn. All comparisons were made to the groups of A549 cells or the cells transfected with vector alone.