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Cortical dysplasia marked by cortical thickening and gray-white boundary blurring in Patient 3.

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posted on 20.02.2013, 20:49 by Thomas Thesen, Brian T. Quinn, Chad Carlson, Orrin Devinsky, Jonathan DuBois, Carrie R. McDonald, Jacqueline French, Richard Leventer, Olga Felsovalyi, Xiuyuan Wang, Eric Halgren, Ruben Kuzniecky

A. Significantly increased thickening of the cortical ribbon (in red/yellow) detected by the automated quantitative approach falls within the expert-delineated area of focal cortical dysplasia (green tracing on the inflated pial surface). The area with highest z-score shows cortical thickness measures of up to 6.5 mm between white matter and pial surfaces. B. Calculating the T1-signal contrast at .5 mm above vs below the gray/white interface shows an area of significant blurring within the lesion. The green circle on the left shows the area of maximum blurring on a coronal volumetric MRI slice.

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