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Correlation between the numbers of CHMP2B-positive GVDs with numbers of GVDs immunoreactive for pSmad2/3 or Ub and hippocampal tau pathology.

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posted on 03.11.2011, 01:56 by Yuu Yamazaki, Tomoyasu Matsubara, Tetsuya Takahashi, Takashi Kurashige, Eisuke Dohi, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumoto

A: Number of neurons with CHMP2B-positive GVDs plotted against those with GVDs immunoreactive for pSmad2/3 (blue filled circles) or ubiquitin (Ub; red open circles). The Pearson correlation coefficient for pSmad2/3 and ubiquitin was 0.935 (p<0.01) and 0.888 (p<0.01), respectively, among all the cases studied. Each circle represents an individual hippocampus investigated. B: Relationship between phosphorylated tau score (p-tau score) and the number of neurons with CHMP2B-positive GVDs in non-Alzheimer's disease (AD) neurodegenerative disorders. The number of neurons with CHMP2B-positive GVDs increased significantly with the score for phosphorylated tau pathology (r = 0.60, p<0.01). Each closed circle represents an individual non-AD hippocampus investigated. Each open circle represents an individual hippocampus from an AD case, for reference. C: CHMP2B-positive GVD burden in the hippocampus with respect to Braak NFT stage in non-Alzheimer's disease (AD) neurodegenerative disorders. The number of neurons with CHMP2B-positive GVDs increased significantly with respect to Braak NFT stage (r = 0.73, p<0.01). Each closed circle represents an individual non-AD hippocampus investigated. Each open circle represents an individual hippocampus from an AD case for reference.

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