Correlation between metabolome of lactobacilli and fungistatic/fungicidal activity towards C. albicans and C. non-albicans.

(A) Biplot of a PCA performed on the total metabolites identified by ¹H-NMR in Lactobacillus cell free supernatants. Expl. Var, explained variance. (B) Box plots representing the distribution of Lactobacillus species in relation to the metabolome. Lines within the boxes indicate the median values of the samples groups corresponding to L. crispatus, L. gasseri and L. vaginalis species. (C) Box plots representing the distribution of fungistatic/fungicidal activity scores towards C. albicans and C. non-albicans in relation to the metabolome. Lines within the boxes indicate the median values of the samples groups corresponding to the different activity scores (0–4 for C. albicans; 0–5 for C. non-albicans). Each box represents the interquartile range (25–75th percentile). The bottom and top bars indicate the 10th and 90th percentiles, respectively. Outlier values are indicated (BC10 and BC15).