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Copolymer-mediated induction of CCL22 and CXCL13 in MHC Class II KO mice.

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posted on 2011-12-15, 00:37 authored by Joseph Kovalchin, Jeffrey Krieger, Michelle Genova, Norio Kawamoto, Michael Augustyniak, Kathryn Collins, Troy Bloom, Allyson Masci, Tara Hittinger, Ingrid Dufour, Jack L. Strominger, Eric Zanelli

Female MHC Class II deficient mice and their littermate controls (n = 9–10) were administered one subcutaneous dose of 50 mg/kg YFAK, 50 mg/kg YEAK, or Vehicle Control. Blood was collected and plasma was prepared 30 minutes post administration and tested for CCL22 (A) and CXCL13 (B). Data is shown as mean (pg/mL) ± SEM. Significance was calculated using an unpaired t-test: YFAK or YEAK vs. Vehicle Control + p≤0.05; + + p≤0.01; + + + p≤0.001; + + + + p≤0.0001; YFAK vs. YEAK * p≤0.05; ** p≤0.01.


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