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Contribution to ASD risk of common variation in the neuronal sub-networks.

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posted on 2012-03-08, 00:16 authored by Eyal Ben-David, Sagiv Shifman

Genetic risk scores were calculated for each individual in the AGP and SSC cohorts, based on the genotypes of 79,079 tag SNPs and the association signal in these SNPs in the AGRE cohort. These scores were used to predict ASD status in a logistic regression model. To test the Lightgreen and Salmon modules, the analysis was limited to tag SNPs residing in genes in these modules. In each module and cohort, different series denote different thresholds of P-values, from PT<0.1 to PT<0.5.

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