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Contractility of isolated cardiac myocytes from wild type (WT) and TGF-β1 transgenic (TGF-β1) mice.

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posted on 20.02.2013, 11:31 by Michael Huntgeburth, Klaus Tiemann, Robert Shahverdyan, Klaus-Dieter Schlüter, Rolf Schreckenberg, Marie-Luise Gross, Sonja Mödersheim, Evren Caglayan, Jochen Müller-Ehmsen, Alexander Ghanem, Marius Vantler, Wolfram H. Zimmermann, Michael Böhm, Stephan Rosenkranz

(A) Representative original registrations of cell shortening (dL/L) under basal conditions and upon isoprenaline stimulation (10 µM). (B) Contractile response of isolated cardiomyocytes from WT and TGF-β1 mice to increasing concentrations of isoprenaline (n = 100 in each group). (C) Contractile response of isolated cardiomyocytes to 10 µM isoprenaline in the various treatment groups (n = 97–135 in each group). *p<0.05 vs. WT.

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