Contractility in α1A-TG isolated working hearts.
A, baseline left ventricular systolic pressure (LVSP), dP/dtmax and dP/dtmin of isolated perfused contracting NTL (n = 17) and α1A-TG (n = 24) hearts. B, representative recordings of left ventricular pressure (LVP) and dP/dt at baseline and during A61603 infusion (100 pM). C, composite data obtained from NTL (◊, n = 6) and α1A-TG (•, n = 7) hearts at baseline (C) and dose-response to A61603. Data are shown as the mean ± SEM. *P<0.05, **P<0.01; ***P<0.001 vs. NTL.