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Download fileContractility in α1A-TG isolated working hearts.
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posted on 2014-06-11, 03:06 authored by Ze-Yan Yu, Ju-Chiat Tan, Aisling C. McMahon, Siiri E. Iismaa, Xiao-Hui Xiao, Scott H. Kesteven, Melissa E. Reichelt, Marion C. Mohl, Nicola J. Smith, Diane Fatkin, David Allen, Stewart I. Head, Robert M. Graham, Michael P. FeneleyA, baseline left ventricular systolic pressure (LVSP), dP/dtmax and dP/dtmin of isolated perfused contracting NTL (n = 17) and α1A-TG (n = 24) hearts. B, representative recordings of left ventricular pressure (LVP) and dP/dt at baseline and during A61603 infusion (100 pM). C, composite data obtained from NTL (◊, n = 6) and α1A-TG (•, n = 7) hearts at baseline (C) and dose-response to A61603. Data are shown as the mean ± SEM. *P<0.05, **P<0.01; ***P<0.001 vs. NTL.
