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Conserved sequence motifs of the dynamin superfamily.

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posted on 2013-08-19, 01:33 authored by Julia Wenger, Eva Klinglmayr, Chris Fröhlich, Clarissa Eibl, Ana Gimeno, Manuel Hessenberger, Sandra Puehringer, Oliver Daumke, Peter Goettig

Sequence alignments of representative members of the dynamin superfamily comparing conserved GTP binding motifs and the trans-stabilizing loops important for G dimerization. Conserved key residues that were mutated to alanine in our study are marked with a dot. Species abbreviations are hs, Homo sapiens; rn, Rattus norvegicus; sc, Saccharomyces cerevisiae; dd, Dictyostelium discoideum; at, Arabidopsis thaliana; MxA, interferon-induced GTP-binding protein A; ! represents one of the amino acids of IV; # represents one of the amino acids NDQE.