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Consequences of loss of Notch pathway activity in emc mutant cells.

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posted on 08.01.2015, 03:28 by Tobias Troost, Markus Schneider, Thomas Klein

(A–C) In PsnC1 emcpel double mutant discs, expression of sca is stronger and expands more than in emcpel mutants. Moreover, most sca expressing cells express Hnt, indicating that they became SOPs (compare with Fig. 5C, D). (D–G) Analysis of null mutant emc Psn clones. Clones are labelled by the loss of RFP and outlined in some panels. A large clone in the notum is highlighted by the dashed line. The expression of Hnt in addition to sca-lacZ indicates that most cells of the clone became SOPs, with the exception of the region in the hinge highlighted with the arrow. The arrowhead points to the small anterior region, which is devoid of sca-lacZ and Hnt expression. (G) Magnification of the notal area highlighted with the arrow in (D–F). White scale bar 50µm; cyan scale bar: 10µm.