figshare
Browse
Figure_3.tif (411.66 kB)
Download file

Comparison of the inhibition of TC uptake by bosentan in human and rat hepatocyte cultures and HepaRG cell cultures.

Download (0 kB)
figure
posted on 2013-03-15, 14:50 authored by Monika Szabo, Zsuzsa Veres, Zsolt Baranyai, Ferenc Jakab, Katalin Jemnitz

(A) HepaRG cells were treated with 1 µM of 3H-TC for 300 sec at 4, 24 and 96 h after seeding in the presence of bosentan (10–200 µM), or the vehicle, respectively. (B) Human and (C) rat hepatocytes were treated with 1 µM of 3H-TC for 30 sec at 4, 24 and 72 h (rat) or 4, 120 h (human) after seeding in the presence of bosentan (10–100 µM), or the vehicle, respectively. Values are expressed as mean±SD, assays were run using four wells as one set. All experiments were carried out with hepatocytes from three independent preparations.

History