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Comparison of proportions of CMV-specific CD8 cells and overall CD4/CD8 ratio in seropositive subjects with Alzheimer´s disease (AD) and non-demented controls (ND).

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posted on 14.10.2013, 02:47 by Gabriel Westman, Anna-Karin Lidehall, Peetra Magnusson, Martin Ingelsson, Lena Kilander, Lars Lannfelt, Olle Korsgren, Britt-Marie Eriksson

a) Comparing total cell count for all HLA-types, there is a clear difference with significantly lower proportions of CMV-specific CD8 cells in AD compared to ND group; 1.16 % versus 4.13 % (p=0.0057) b) Comparing only subjects with HLA-A02 tetramer data, there is a trend towards lower proportions of CD8 cells in the AD compared to the ND group; 1.26 % versus 3.07% (p=0.066) c) The overall CD4/CD8-ratio did not differ between groups.