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Combinations of NHAPI or its Fe complex with TMX caused decreases in proliferation and G1-S cell cycle arrest.

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posted on 20.02.2014, 03:40 by Eliska Potuckova, Hana Jansova, Miloslav Machacek, Anna Vavrova, Pavlina Haskova, Lucie Tichotova, Vera Richardson, Danuta S. Kalinowski, Des R. Richardson, Tomas Simunek

The proliferation dynamics were measured as the electrical impedance of MCF-7 cells (A, B, C and D) and were monitored using an xCELLigence System for 72 h. Cell cycle analyses (E and F) were performed following a 72 h/37°C incubation with the agent using flow cytometry following propidium iodide staining. Results are: (A–D) means of n  = 3 experiments and (E, F) mean±SD (n≥4 experiments). Statistical significance (ANOVA): *p<0.05, **p<0.01, ***p<0.001 as compared to the control (untreated) group.