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Closely related retrotransposons are differentially sensitive to loss of Tex19.1.

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posted on 26.04.2012, 01:52 by Judith Reichmann, James H. Crichton, Monika J. Madej, Mary Taggart, Philippe Gautier, Jose Luis Garcia-Perez, Richard R. Meehan, Ian R. Adams

(A) Phylogeny of mouse retrotransposon pol and pro proteins. MMERVK10C sequences are highlighted in red. The MMERVK10C sequences lie within a cluster of IAP-type sequences (yellow). (B) Plot showing the likelihood of IAP probes changing expression in the Tex19.1−/− microarray dataset. (C) qRT-PCR for retrotransposons closely related to MMERVK10C in Tex19.1−/− knockout and littermate control testes at 16 dpp. Expression levels for each repetitive element (mean ± standard error for three animals) were normalized to β-Actin and expressed relative to littermate controls. MMERVK10C env.c and IAP primer sets (Figure S2) were used to assess MMERVK10C and IAPEz expression. Asterisk indicates a statistically significant difference (p<0.05).