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Clinical course of DSS-induced colitis in C3ar-/- vs. WT BALB/c and B6 mice.

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posted on 2013-04-26, 00:37 authored by Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A. Wetsel, Silke Glage, Andreas Klos

Mice were given 3% DSS with the drinking water from day 0–7. Clinical score and weight were determined daily, starting on day –1. Control animals fed with water did not have any clinical signs or weight loss (data not shown). A, Time course of clinical score and B, Time course of body weight. To minimize suffering, three out of 25 B6 WT animals had to be sacrificed on day 6, leading to a seemingly smaller increase of the clinical score, and to a seemingly smaller weight loss, from day 6 to day 7, as compared to the preceding days. The data shown are means ± SEM of two independent trials with a total of n = 33 WT mice and n = 32 C3ar-/- mice for BALB/c, and of four independent trials with a total of n = 25 (day 0–6) or n = 22 (day 7) WT mice and n = 21 C3ar-/- mice for C57BL/6. *, p<0.05; **, p<0.01; ***, p<0.001.